&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;OVERVIEW&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Initial testing for disseminated intravascular coagulation (DIC) includes prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen, and D-dimer, along with the DIC/intravascular coagulation and fibrinolysis (ICF) profile. If PT is elevated (&amp;gt;13.9 sec), a PT mix is performed. For an increased aPTT (&amp;ge;38 sec), aPTT mix and dilute Russell&#39;s viper venom time (dRVVT) tests are initiated. A dRVVT ratio &amp;ge;1.20 leads to dRVVT mix and confirmation. Low fibrinogen (&amp;lt;150 mg/dL) triggers PT-fibrinogen testing, while high D-dimer (&amp;gt;500 ng/mL) requires soluble fibrin monomer testing. Platelet neutralization is done for aPTT mix &amp;ge;38 sec and TT &amp;lt;35.0 sec, and reptilase time is tested for TT &amp;ge;25.0 sec. Methods include PTSC, APTSC, TTSC (optical clot-based), CLFIB (Clauss), and DIMER (Latex Immunoassay), with interpretation provided by ADICI. Specimens needed are platelet-poor plasma collected in light-blue top tubes.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;hr /&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;TESTING ALGORITHM&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Initial testing comprises prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen, D-dimer, and interpretation of disseminated intravascular coagulation/intravascular coagulation and fibrinolysis (DIC/ICF) profile. If PT exceeds 13.9 seconds, the PT mix will be conducted at an extra cost. Similarly, if aPTT equals or exceeds 38 seconds, aPTT mix and dilute Russell&#39;s viper venom time (dRVVT) tests will be performed for an additional fee. A dRVVT ratio of 1.20 or higher prompts dRVVT mix and dRVVT confirmation at an extra charge. Fibrinogen levels below 150 mg/dL or as clinically indicated trigger PT-fibrinogen testing at an additional cost. D-dimer levels surpassing 500 ng/mL fibrinogen equivalent units necessitate soluble fibrin monomer testing for an additional charge. The platelet neutralization procedure will be conducted at an additional cost for aPTT mix equal to or exceeding 38 seconds and TT below 35.0 seconds (indicating no heparin presence).&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;If TT equals or exceeds 25.0 seconds, reptilase time testing will be performed for an additional fee.&lt;/span&gt;&lt;/p&gt;
&lt;div class=&quot;w-full pt-2 md:pt-0 dark:border-white/20 md:border-transparent md:dark:border-transparent md:w-[calc(100%-.5rem)]&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;METHOD NAME&lt;/span&gt;&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;PTSC, APTSC, TTSC: Optical Clot-Based&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;CLFIB: Clauss&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;DIMER: Latex Immunoassay (LIA)&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;ADICI: Medical Interpretation&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;br /&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;AVAILABILITY&lt;/span&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;DIC/ICF Prof&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;br /&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;ALIASES&lt;/span&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;DIC/ICF Profile&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;intravascular&lt;/span&gt;&lt;/p&gt;

&lt;h3&gt;&amp;nbsp;&lt;/h3&gt;
&lt;h3 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Plasma Na Cit&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;SHIPPING INSTRUCTIONS&lt;/span&gt;&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN REQUIRED&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Type:&lt;/strong&gt;&amp;nbsp;Platelet-poor plasma&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Patient Preparation:&lt;/strong&gt;&amp;nbsp;The patient should not be receiving Coumadin or heparin. If so, note on request.&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Collection Container/Tube:&lt;/strong&gt;&amp;nbsp;Light-blue top (3.2% sodium citrate)&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Submission Container/Tube:&lt;/strong&gt;&amp;nbsp;5 Plastic vials&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Volume:&lt;/strong&gt;&amp;nbsp;5 mL in 5 plastic vials, each containing 1 mL&lt;/span&gt;&lt;/p&gt;

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Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma