&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;OVERVIEW&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The Ewing sarcoma breakpoint region 1 (EWSR1) gene is vital in cellular processes, acting as a transcriptional regulator and influencing the activities of various proteins. Initially, the oncogenic fusion of EWSR1 with FLI1 at 11q24 or with ERG at 21q22, caused by chromosomal translocations (t(11;22) and t(21;22), respectively), was identified as a hallmark of Ewing sarcoma. Later, fusion events involving EWSR1 and other partner genes have been found in a wide range of neoplastic conditions.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;hr /&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;METHOD NAME&lt;/span&gt;&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Fluorescence In Situ Hybridization (FISH)&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;AVAILABILITY&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;EWSR1 (22q12), FISH, Ts&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;ALIASES&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;-&lt;/span&gt;&lt;/p&gt;

&lt;h3&gt;&amp;nbsp;&lt;/h3&gt;
&lt;h3 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Tissue&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;SHIPPING INSTRUCTIONS&lt;/span&gt;&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN REQUIRED&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span class=&quot;normaltextrun&quot; style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Submit only 1 of the following specimens:&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Preferred&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;eop&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Specimen Type:&amp;nbsp;&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;Tissue block&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Collection Instructions:&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&amp;nbsp;Submit a formalin-fixed, paraffin-embedded tumor tissue block. Blocks prepared with alternative fixation methods may be acceptable; provide fixation method used.&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span class=&quot;normaltextrun&quot; style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Acceptable&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Specimen Type:&amp;nbsp;&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;Tissue slides&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Slides&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;: 1 Hematoxylin and eosin stained and 4 unstained&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Collection Instructions&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;: Submit 1 slide stained with hematoxylin and eosin and 4 consecutive unstained, positively-charged, unbaked slides with 5 micron-thick sections of the tumor tissue.&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;

Lysosomal and Peroxisomal Disorders Screen, Blood Spot

Lysosomal Storage Disease Gene Panel, Varies

Ewing Sarcoma, 22q12 (EWSR1) Rearrangement, FISH, Tissue