&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;OVERVIEW&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The HER2 Amplification in Breast Cancer test, performed using Fluorescence In Situ Hybridization (FISH) on tissue samples, detects HER2 gene amplification in breast cancer cells. This test is essential for determining the HER2 status of tumors, guiding treatment decisions, particularly for targeted therapies such as trastuzumab (Herceptin). It offers crucial insights into tumor aggressiveness and supports personalized treatment planning.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;hr /&gt;
&lt;h2&gt;&amp;nbsp;&lt;/h2&gt;
&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;WHAT IS IT USED FOR?&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Predictive indicator for patients with node-positive or node-negative breast cancer, both primary and metastatic.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Patients with HER2 amplification who may benefit from therapies targeting the HER2 protein.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Confirming HER2 amplification in cases with 2+ or 3+ HER2 overexpression by immunohistochemistry, and certain histologic subtypes with abnormal HER2 expression patterns.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;h2&gt;&amp;nbsp;&lt;/h2&gt;
&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;METHOD NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Fluorescence In Situ Hybridization (FISH)&lt;/span&gt;&lt;/p&gt;
&lt;h2&gt;&amp;nbsp;&lt;/h2&gt;
&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;AVAILABILITY&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;h2&gt;&amp;nbsp;&lt;/h2&gt;
&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;div id=&quot;ReportingName-value&quot;&gt;
&lt;div id=&quot;ReportingName-value&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;HER2, Breast Tumor, FISH, Tissue&lt;/span&gt;&lt;/div&gt;
&lt;div&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/div&gt;
&lt;div&gt;
&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;OTHER NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Breast Carcinoma&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;c-erb-b2 Amplification Test (FISH)&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;/div&gt;

&lt;h2&gt;&amp;nbsp;&lt;/h2&gt;
&lt;h2 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Tissue&lt;/span&gt;&lt;/p&gt;
&lt;h2&gt;&amp;nbsp;&lt;/h2&gt;
&lt;h2&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;SHIPPING INSTRUCTIONS&lt;/span&gt;&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN REQUIRED&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Specimen Type:&amp;nbsp;&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;Tissue block&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Collection instructions:&amp;nbsp;&lt;/strong&gt;Collect blood in a regular red-top tube or a serum gel tube. Centrifuge and send 1 mL of frozen serum in a screw-capped vial.&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;p class=&quot;paragraph&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Specimen Type:&amp;nbsp;&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;Tissue slides&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Slides:&lt;/strong&gt; 1 Hematoxylin and eosin stained and 4 unstained&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;span class=&quot;normaltextrun&quot;&gt;&lt;strong&gt;Collection Instructions&lt;/strong&gt;&lt;/span&gt;&lt;span class=&quot;normaltextrun&quot;&gt;:&amp;nbsp;&lt;/span&gt;Please provide one slide stained with hematoxylin and eosin, along with four consecutive, unstained slides with positively charged surfaces and 5-micron-thick sections of the tumor tissue. Slides from blocks prepared with alternative fixation methods may be accepted; specify the fixation method used.&lt;/span&gt;&lt;/p&gt;

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HER2 Amplification Associated with Breast Cancer, FISH, Tissue