&lt;h2&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Overview&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
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&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Programmed Death-Ligand 1 (PD-L1) (22C3) semi-quantitative immunohistochemistry (IHC) is a diagnostic technique used to assess the expression levels of PD-L1 protein in tissue samples. PD-L1 is a protein found on the surface of some cancer cells and immune cells. Its interaction with PD-1 receptors on T cells can suppress the immune response, allowing cancer cells to evade detection by the immune system.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;In clinical practice, PD-L1 testing is crucial for determining whether a patient with certain types of cancer may benefit from treatment with immune checkpoint inhibitors (ICIs). These inhibitors target the PD-1/PD-L1 pathway, enhancing the immune system&#39;s ability to recognize and attack cancer cells.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;The 22C3 antibody is specifically designed to detect PD-L1 and is used in a semi-quantitative manner to assess the proportion of tumor cells expressing PD-L1. The results are reported as the percentage of positively stained cells or as a combined positive score (CPS), which includes both tumor and immune cell staining.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;This manual IHC method involves staining tissue sections with the 22C3 antibody, followed by visual examination under a microscope and interpretation by pathologists. It helps oncologists make informed decisions regarding treatment options, particularly with ICIs, by predicting response rates and guiding personalized therapy plans.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Overall, PD-L1 (22C3) semi-quantitative immunohistochemistry plays a critical role in oncology by providing valuable information about the immune status of tumors and aiding in the selection of appropriate immunotherapy strategies for cancer patients.&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;WHAT IS IT USED FOR?&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
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&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Detection of tumors that express programmed cell death 1-ligand 1 (clone 22C3).&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;METHOD NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Immunohistochemistry (IHC)&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;&lt;br /&gt;AVAILABILITY&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;PD-L1 (22C3) SemiQuant IHC, Manual&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;ALIASES&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;PDL1&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;22C3&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;ISPDL122C3IHC&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;GPPDL122C3&lt;/span&gt;&lt;/li&gt;
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&lt;h3 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Special&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SHIPPING INSTRUCTIONS&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN REQUIRED&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Specimen Type:&lt;/strong&gt;&amp;nbsp;Tissue&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;Supplies:&lt;/strong&gt;&amp;nbsp;Pathology Packaging Kit&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Collection Instructions:&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;Formalin-fixed, paraffin-embedded tissue block; or 3 unstained glass, &quot;positively charged&quot; slides with 4-microns formalin-fixed, paraffin-embedded tissue&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Additional Information:&lt;/strong&gt;&lt;/span&gt;&amp;nbsp;One slide will be stained with hematoxylin and eosin and returned.&lt;/span&gt;&lt;/p&gt;

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Programmed Death-Ligand 1 (PD-L1) (22C3), Semi-Quantitative Immunohistochemistry, Manual