&lt;h2&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;OVERVIEW&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;font-size: 14px; color: #99ccff;&quot;&gt;The Thiopurine Methyltransferase (TPMT) and Nudix Hydrolase (NUDT15) Genotyping test is essential for predicting the potential toxicity associated with thiopurine drugs, including 6-mercaptopurine, 6-thioguanine, and azathioprine. This analysis utilizes Real-Time Polymerase Chain Reaction (PCR) with Allelic Discrimination Analysis to assess the genetic profile related to TPMT and NUDT15 variants. The test is reported under the name &quot;TPMT and NUDT15 Genotype, V,&quot; indicating its focus on genetic analysis. It is also known by various aliases, including specific drug names like 6-Mercaptopurine and Azathioprine, as well as conditions such as Crohn&#39;s Disease and Ulcerative Colitis, highlighting its clinical significance across different medical contexts.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;hr /&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;METHOD NAME&lt;/span&gt;&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Real-Time Polymerase Chain Reaction (PCR) With Allelic Discrimination Analysis&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;br /&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;AVAILABILITY&lt;/span&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
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&lt;div id=&quot;ReportingName-value&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TPMT and NUDT15 Genotype, V&lt;/span&gt;&lt;/div&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;br /&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;ALIASES&lt;/span&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
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&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;6-Mercaptopurine&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;6-Thioguanine&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Acute Lymphoblastic Leukemia (ALL)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Azathioprine&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Crohn&#39;s Disease&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Inflammatory Bowel Disease (IBD)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;NUDT15&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Rheumatoid Arthritis&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Thiopurine&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TPMT&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Ulcerative Colitis&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;mercaptopurine&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;thioguanine&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;tmpt&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&amp;nbsp;&lt;/h3&gt;
&lt;h3 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Varies&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;SHIPPING INSTRUCTIONS&lt;/span&gt;&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #ff99cc;&quot;&gt;&lt;strong&gt;SPECIMEN REQUIRED&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;div class=&quot;markdown prose w-full break-words dark:prose-invert light&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Multiple genotype tests can be performed on a single specimen after a single extraction.&lt;/span&gt;&lt;/div&gt;
&lt;div class=&quot;markdown prose w-full break-words dark:prose-invert light&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;markdown prose w-full break-words dark:prose-invert light&quot;&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Type: &lt;/strong&gt;Whole blood&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Container/Tube: &lt;/strong&gt;Lavender top (EDTA)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Volume:&lt;/strong&gt; 3 mL&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Collection Instructions:&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Invert several times to mix blood.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Send whole blood specimen in original tube. &lt;strong&gt;Do not aliquot.&lt;/strong&gt;&lt;/span&gt;&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Stability Information:&lt;/strong&gt; Ambient (preferred) 9 days/Refrigerated 30 days&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Type:&lt;/strong&gt; Saliva&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Patient Preparation: &lt;/strong&gt;Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Supplies: &lt;/strong&gt;Saliva Swab Collection Kit (T786)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Volume: &lt;/strong&gt;1 Swab&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Collection Instructions: &lt;/strong&gt;Collect and send specimen per kit instructions.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Stability Information:&lt;/strong&gt; Ambient 30 days&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Type&lt;/strong&gt;: Extracted DNA&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Container/Tube&lt;/strong&gt;: 2-mL screw top tube&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen&lt;/strong&gt;&lt;strong&gt; Volume&lt;/strong&gt;: 100 mcL&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Collection Instructions&lt;/strong&gt;:&lt;/span&gt;&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The preferred volume is 100 mcL at a concentration of 50 ng/mcL.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Provide concentration of DNA and volume on tube.&lt;/span&gt;&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;strong&gt;Specimen Stability Information&lt;/strong&gt;: Frozen (preferred)/Ambient/Refrigerated&lt;/span&gt;&lt;/p&gt;
&lt;/div&gt;

5-Hydroxyindoleacetic Acid, Plasma

5-Hydroxyindoleacetic Acid, Random, Urine

Thiopurine Methyltransferase (TPMT) and Nudix Hydrolase (NUDT15) Genotyping, Varies